Leukemoid reaction response to chemotherapy and radiotherapy in a patient with cervical carcinoma.

Abstract

A white blood cell count more than 50 x 10(9)/l associated with a cause outside the bone marrow is termed a leukemoid reaction. Although it simulates leukemia, most of its causes are benign. Malignancy as a cause of a leukemoid reaction is still a medical dilemma. It is thought to be attributed to granulocyte colony-stimulating factor (G-CSF) secreted by the tumor cells. To our knowledge this is the first time a leukemoid reaction has been reported in association with cervical cancer. We even managed to monitor the leukemoid reaction response to chemotherapy and radiotherapy.

• Authors: H S Nimieri, S N Makoni, F H Madziwa, D S Nemiary
• Journal: Annals of hematology (Ann Hematol) Vol. 82 Issue 5 Pg. 316-7 (May 2003) ISSN: 0939-5555 [Print] Germany
• PMID: 12739065 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Biomarkers, Tumor

Topics

• Aged
• Aged, 80 and over
• Antineoplastic Agents (adverse effects)
• Biomarkers, Tumor (blood)
• Carcinoma, Squamous Cell (blood, complications, diagnosis)
• Combined Modality Therapy (adverse effects)
• Diagnosis, Differential
• Fatal Outcome
• Female
• Humans
• Leukemoid Reaction (etiology)
• Leukocyte Count
• Radiotherapy (adverse effects)
• Uterine Cervical Neoplasms (blood, complications, diagnosis)