Abstract |
A chitosan (CS)- orotic acid salt (CS-OT) was prepared, and the release of orotic acid (OT) from CS-OT as well as the adsorption of bile acids by CS-OT was investigated in vitro. The amount of OT released from CS-OT was about 2-2.7 micromol/mg CS-OT and this changed depending on the species of CS. CS-OT also adsorbed bile acids and the amount increased incrementally according to the number of amino group contained in CS. Furthermore, CS-OT was given to rats as feed in order to investigate the influence on serum cholesterol levels. A decrease in serum cholesterol levels was observed in the group, which was fed a diet containing CS-OT or CS for 1-2 weeks, but no differences in body weight changes were recognized. Therefore, CS-OT may be applied to treating hyperlipidemia.
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Authors | Yoshifumi Murata, Naoko Kojima, Susumu Kawashima |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 26
Issue 5
Pg. 687-90
(May 2003)
ISSN: 0918-6158 [Print] Japan |
PMID | 12736513
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Pharmaceutic
- Bile Acids and Salts
- Drug Combinations
- Hypolipidemic Agents
- Triglycerides
- Chitin
- Orotic Acid
- Chitosan
- Cholesterol
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Topics |
- Adjuvants, Pharmaceutic
(chemistry, pharmacology)
- Administration, Oral
- Adsorption
- Animals
- Bile Acids and Salts
(chemistry)
- Body Weight
(drug effects)
- Chitin
(analogs & derivatives, chemistry, pharmacology)
- Chitosan
- Cholesterol
(blood)
- Diet
- Drug Combinations
- Gastrointestinal Tract
(metabolism)
- Hypolipidemic Agents
(chemistry, pharmacology)
- In Vitro Techniques
- Male
- Orotic Acid
(chemistry, pharmacology)
- Rats
- Rats, Wistar
- Time Factors
- Triglycerides
(blood)
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