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Heterocyclic compounds as inflammation inhibitors.

Abstract
Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with significant toxicity particularly in the gastrointestinal tract and kidney. Various approaches such as formulation co-administration (of agents to protect the stomach), chemical manipulation and synthesis of new safer anti-inflammatory drugs reported in the literature to overcome the toxicity of NSAIDs have been summarized. As far as synthesis of new more effective and safer anti-inflammatory drugs is concerned, we have reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidines, imidazole, benzimidazole, thiazole, thiazolidine, acridine, thiourea, alkanoic acid derivatives and other related heterocyclic compounds and their role as inflammation inhibitors.
AuthorsSham M Sondhi, Nidhi Singhal, Monika Johar, B S Narayan Reddy, J William Lown
JournalCurrent medicinal chemistry (Curr Med Chem) Vol. 9 Issue 10 Pg. 1045-74 (May 2002) ISSN: 0929-8673 [Print] United Arab Emirates
PMID12733983 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Acridines
  • Alkanes
  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzimidazoles
  • Carboxylic Acids
  • Heterocyclic Compounds
  • Imidazoles
  • Pyrimidines
  • Thiazoles
  • imidazole
  • benzimidazole
  • Thiourea
Topics
  • Acridines (chemical synthesis, pharmacology)
  • Alkanes (chemical synthesis, pharmacology)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (adverse effects, chemical synthesis, chemistry, pharmacology)
  • Benzimidazoles (chemical synthesis, pharmacology)
  • Carboxylic Acids (chemical synthesis, pharmacology)
  • Gastrointestinal Diseases (chemically induced)
  • Heterocyclic Compounds (adverse effects, chemical synthesis, chemistry, pharmacology)
  • Humans
  • Imidazoles (chemical synthesis, pharmacology)
  • Pyrimidines (chemical synthesis, pharmacology)
  • Thiazoles (chemical synthesis, pharmacology)
  • Thiourea (analogs & derivatives, chemical synthesis, pharmacology)

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