The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats.

Abstract

The aim of the study was to examine the influence of the blockade of group I metabotropic glutamate receptors (mGluRs) on the haloperidol-induced catalepsy and proenkephalin mRNA expression in the rat striatum. Bilateral, intrastriatal injection of AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid, 3-15 microg/0.5 microl), a selective antagonist of group I mGluRs, inhibited catalepsy induced by haloperidol (0.5 mg/kg i.p.). Repeated intrastriatal AIDA administrations (3 x 15 microg/0.5 microl, 3 h apart) counteracted the haloperidol-induced (3 x 1.5 mg/kg s.c., 3 h apart) increase in the proenkephalin mRNA expression in that structure. The present study indicates that the blockade of the striatal group I mGluRs may inhibit parkinsonian akinesia by normalizing the function of the striopallidal pathway.

• Authors: Krystyna Ossowska, Jadwiga Wardas, Małgorzata Pietraszek, Jolanta Konieczny, Stanisław Wolfarth
• Journal: Neuroscience letters (Neurosci Lett) Vol. 342 Issue 1-2 Pg. 21-4 (May 15 2003) ISSN: 0304-3940 [Print] Ireland
• PMID: 12727308 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dopamine Antagonists
• Enkephalins
• Protein Precursors
• RNA, Messenger
• Receptors, Metabotropic Glutamate
• metabotropic glutamate receptor type 1
• proenkephalin
• Haloperidol

Topics

• Animals
• Cataplexy (chemically induced, drug therapy, metabolism)
• Corpus Striatum (drug effects, metabolism)
• Dopamine Antagonists
• Enkephalins (drug effects, metabolism)
• Globus Pallidus (drug effects, metabolism)
• Haloperidol
• Male
• Neural Pathways (metabolism)
• Parkinson Disease (metabolism)
• Protein Precursors (drug effects, metabolism)
• RNA, Messenger (metabolism)
• Rats
• Rats, Wistar
• Receptors, Metabotropic Glutamate (antagonists & inhibitors, metabolism)