[Possible role of transforming growth factor alpha on the cholesteatoma growth regulation].

Abstract

OBJECTIVE:

To investigate the mode of expression and distribution of transforming growth factor alpha in middle ear cholesteatoma.

METHOD:

The specimens from the cholesteatoma tissue of 32 cases and the normal external ear skin of 10 cases were examined by immunohistochemical S-P method and computer image analysis.

RESULT:

In cholesteatoma epithelium staining for TGF alpha was consistently stronger than that in normal epithelium. The mean absorbance of the two epithelial tissue is 2.431 +/- 0.587 and 1.463 +/- 0.147 respectively, revealing a significant difference. Some immune cells infiltrating the stroma of cholesteatoma also stained positively for TGF alpha.

CONCLUSION:

These data suggested that an autocrine and paracrine stimulation of the squamous epithelium of cholesteatoma by TGF might contribute to its hyperproliferation.

• Authors: Yu Xu, Zhanyuan Wu, Zezhang Tao, Qingquan Hua, Kangye Jin
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 17 Issue 1 Pg. 32-4 (Jan 2003) China
• PMID: 12725186 (Publication Type: English Abstract, Journal Article)

Chemical References

• Transforming Growth Factor alpha

Topics

• Adolescent
• Adult
• Child
• Cholesteatoma, Middle Ear (metabolism, pathology)
• Epidermis (pathology)
• Female
• Humans
• Male
• Middle Aged
• Transforming Growth Factor alpha (biosynthesis, physiology)