Clinical outcome observed in subjects with recurrent periodontal disease following local treatment with 25% metronidazole gel.

Abstract

BACKGROUND:

The aim of this study was to evaluate the clinical outcome in patients with recurrent periodontal disease following treatment with 25% metronidazole gel.

METHODS:

Twenty subjects in a maintenance care program but with recurrent periodontal disease participated. Three months after scaling and root planing, a total of 40 sites, 2 in each patient, with probing depth > or = 5 mm were selected. One site randomly selected was treated with metronidazole gel (test) and the other site with a placebo gel (control). Baseline and follow-up measurements included plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL).

RESULTS:

There were no statistically significant differences in PI, GI, BOP, PD, or CAL between test and control sites.

CONCLUSION:

This study showed that local treatment with 25% metronidazole gel did not seem to influence the clinical healing in this group of subjects with recurrent periodontal disease.

• Authors: H Jansson, G Bratthall, G Söderholm
• Journal: Journal of periodontology (J Periodontol) Vol. 74 Issue 3 Pg. 372-7 (Mar 2003) ISSN: 0022-3492 [Print] United States
• PMID: 12710758 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Gels
• Placebos
• Metronidazole

Topics

• Adult
• Anti-Infective Agents (administration & dosage, therapeutic use)
• Dental Plaque Index
• Dental Scaling
• Follow-Up Studies
• Gels
• Gingival Hemorrhage (drug therapy)
• Humans
• Metronidazole (administration & dosage, therapeutic use)
• Middle Aged
• Periodontal Attachment Loss (drug therapy)
• Periodontal Diseases (drug therapy)
• Periodontal Index
• Periodontal Pocket (drug therapy)
• Placebos
• Recurrence
• Root Planing
• Statistics, Nonparametric
• Treatment Outcome