Nitric oxide metabolities in acute rheumatic fever.

Abstract

Acute rheumatic fever (ARF), is a systemic inflammatory disease etiologically related to infection with group A beta hemolytic streptococcus, characterized by a broad spectrum of disorders in cellular immunity. To estimate the activity of the immunopathological process in patients with ARF, plasma nitric oxide metabolities (NOx) concentrations, IL-1alpha and IL-2 levels were investigated in 22 patients with ARF at the time on admission, and after 3 months, in children with chronic rheumatic heart disease (CRHD). Plasma NOx concentrations, IL-1alpha and IL/2 levels in patients with ARF on admission were significantly higher than in the same patients 3 months later, and higher than in CRHD, or controls. Increased plasma NO may be a useful index for the quantitative assessment of the activity during immunological challenge. This information may be useful for the prognosis and monitoring of ARF.

• Authors: Figen Narin, Nazmi Narin, Hatice Pasaoğlu, Canan Halici, Duran Aslan
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 199 Issue 3 Pg. 135-9 (Mar 2003) ISSN: 0040-8727 [Print] Japan
• PMID: 12703657 (Publication Type: Journal Article)

Chemical References

• Interleukin-1
• Interleukin-2
• Nitric Oxide

Topics

• Acute Disease
• Adolescent
• Age Factors
• Child
• Female
• Humans
• Interleukin-1 (blood)
• Interleukin-2 (blood)
• Male
• Nitric Oxide (blood, metabolism)
• Prognosis
• Rheumatic Fever (metabolism)
• Time Factors