Abstract | BACKGROUND: METHODS: RESULTS: Magnetic resonance imaging (MRI) showed meningeal enhancement and single-photon emission computed tomography (SPECT) showed markedly reduced tracer uptake. Discontinuation of OKT3 resulted in resolution of this neuropsychiatric syndrome and reversal of abnormalities on neuroimaging that coincided with normalization of CD3+ lymphocyte count. CONCLUSIONS: In the initial posttransplant period, it remains difficult to attribute encephalopathic signs to toxicity of immunosuppressive drugs. However, MRI and cerebral perfusion studies may help support the diagnosis. More precise characterization of the prevalence of OKT3-associated encephalopathy could come from prospective SPECT studies.
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Authors | Sean J Pittock, Alejandro A Rabinstein, Brooks S Edwards, Eelco F M Wijdicks |
Journal | Transplantation
(Transplantation)
Vol. 75
Issue 7
Pg. 1058-60
(Apr 15 2003)
ISSN: 0041-1337 [Print] United States |
PMID | 12698102
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Muromonab-CD3
- Neurotoxins
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Topics |
- Adult
- Akinetic Mutism
(chemically induced, physiopathology)
- Animals
- Heart Transplantation
- Humans
- Immunosuppressive Agents
(administration & dosage, poisoning)
- Magnetic Resonance Imaging
- Male
- Mice
- Muromonab-CD3
(administration & dosage, poisoning)
- Neurotoxins
- Recovery of Function
- Tomography, Emission-Computed, Single-Photon
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