Abstract | BACKGROUND/AIMS: METHODS: The effect of ciglitazone on apoptosis and cell growth of cultured NRKs and MMCs was done using DNA fragmentation and MTS cell-growth assays, respectively. The potential role of PPAR-gamma in these two cell types was examined by reporter gene analysis. RESULTS: CONCLUSIONS: Apoptotic and negative growth effects of ciglitazone, in NRKs, are not mediated through PPAR-gamma. The thiazolidinediones have important cellular effects on renal interstitial fibroblasts and glomerular mesangial cells that may be therapeutically useful in non-diabetic renal disease.
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Authors | Narayanan Parameswaran, Carolyn S Hall, Jennifer M Bomberger, Harvey V Sparks, Donald B Jump, William S Spielman |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 26
Issue 1
Pg. 2-9
( 2003)
ISSN: 1420-4096 [Print] Switzerland |
PMID | 12697971
(Publication Type: Journal Article)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- Hypoglycemic Agents
- Ligands
- Receptors, Cytoplasmic and Nuclear
- Thiazolidinediones
- Transcription Factors
- Caspases
- ciglitazone
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Topics |
- Animals
- Apoptosis
(drug effects, physiology)
- Caspases
(metabolism)
- Cell Division
(drug effects, physiology)
- Cells, Cultured
- Fibroblasts
(cytology, drug effects)
- Glomerular Mesangium
(cytology)
- Hypoglycemic Agents
(pharmacology)
- Ligands
- Mice
- Receptors, Cytoplasmic and Nuclear
(genetics, metabolism)
- Thiazolidinediones
(pharmacology)
- Transcription Factors
(genetics, metabolism)
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