[Hypermethylation status of blu gene in nasopharyngeal lymphoma].

Abstract

OBJECTIVE:

To investigate the hypermethylation status of blu gene promoter in nasopharyngeal NK/T cell lymphoma and its role in the tumorigenesis and molecular diagnosis of this lymphoma.

METHODS:

Twenty cases of paraffin-embedded nasopharyngeal NK/T cell lymphomas tissues were studied by using methylation specific PCR (MSP).

RESULTS:

Hypermethylation of blu gene promoter is detected in 6 of 20 (30%) nasopharyngeal NK/T cell lymphoma. The 6 positive cases were 4 in 15 nasopharyngeal NK cell lymphomas, 1 of 2 NK like T cell lymphoma and 1 in 3 peripheral T cell lymphomas (unspecified type).

CONCLUSION:

Hypermethylation of blu gene promoter in nasopharyngeal NK/T cell lymphoma indicated the inactivation of blu gene and its possible role in the tumorigenesis of this lymphoma. blu gene methylation could be detected in paraffin-embedded tissue and used as a new molecular marker for the diagnosis of this lymphoma.

• Authors: Xiao-hua Zhang, Fen Jiang, Min Li, Qing Xu, Ning Li, Qian Tao, Zi-fen Gao
• Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 24 Issue 3 Pg. 138-40 (Mar 2003) ISSN: 0253-2727 [Print] China
• PMID: 12697125 (Publication Type: Journal Article)

Chemical References

• Cytoskeletal Proteins
• Tumor Suppressor Proteins
• ZMYND10 protein, human

Topics

• Cytoskeletal Proteins
• DNA Methylation
• Genes, Tumor Suppressor
• Humans
• Lymphoma (genetics, pathology)
• Nasopharyngeal Neoplasms (genetics, pathology)
• Polymerase Chain Reaction (methods)
• Tumor Suppressor Proteins