HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Rationale and evidence for the use of oxcarbazepine in neuropathic pain.

Abstract
Oxcarbazepine is a second-generation antiepileptic drug (AED) with proven efficacy in managing partial epileptic seizures, with or without secondary generalization, in adults and children. The overlap between the underlying pathophysiologic mechanisms of some epilepsy models and neuropathic pain models supports the rationale for using certain AEDs in the treatment of neuropathic pain. Several AEDs have reportedly produced analgesia in a range of neuropathic pains, including painful diabetic neuropathy (PDN) and post-herpetic neuralgia. Increasing evidence suggests that oxcarbazepine can provide significant analgesia in several neuropathic pain conditions, including trigeminal neuralgia and PDN, and is also may be effective in treating neuropathic pain refractory to other AEDs, such as carbamazepine and gabapentin. The analgesic effects of oxcarbazepine, and its generally improved safety and tolerability profile compared with other standard AEDs, suggests that oxcarbazepine will be an important addition to the neuropathic pain armamentarium. The rationale and evidence to support the efficacy of oxcarbazepine are presented here.
AuthorsEnrique Carrazana, Imao Mikoshiba
JournalJournal of pain and symptom management (J Pain Symptom Manage) Vol. 25 Issue 5 Suppl Pg. S31-5 (May 2003) ISSN: 0885-3924 [Print] United States
PMID12694990 (Publication Type: Journal Article, Review)
Chemical References
  • Anticonvulsants
  • Carbamazepine
  • oxcarbazepine
Topics
  • Anticonvulsants (therapeutic use)
  • Carbamazepine (administration & dosage, analogs & derivatives)
  • Central Nervous System Diseases (complications, drug therapy)
  • Clinical Trials as Topic
  • Diabetic Neuropathies (complications, drug therapy)
  • Evidence-Based Medicine (methods)
  • Humans
  • Neuralgia (diagnosis, drug therapy, etiology)
  • Pain (drug therapy, etiology)
  • Peripheral Nervous System Diseases (complications, drug therapy)
  • Therapeutics
  • Trigeminal Neuralgia (complications, drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: