Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.

Abstract

OBJECTIVES:

The aim of this double-blind, parallel study was to test the clinical efficacy of a newly developed mouthrinse in the treatment of oral halitosis in patients without periodontitis.

MATERIAL AND METHODS:

Forty volunteers, recruited in two centers, participated in this study. Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score>1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC)>170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI)>4 (0-12). Intervention included gargling with a mouthrinse containing chlorhexidine (0.05%), cetylpyridinium chloride (0.05%) and zinc-lactate (0.14%) or with a placebo mouthrinse without active ingredients. At days 0 and 14 clinical variables were assessed in order of performance: (1) organoleptic assessments, (2) levels of VSC, and (3) WTCI.

RESULTS:

Treatment with the active mouthrinse resulted in a significant mean reduction in the organoleptic score from 2.8 to 1.5 (p<0.005). In the placebo group, no significant reduction in the mean organoleptic score occurred. Consequently, this resulted, after 2 weeks, in a greater change of the organoleptic scores in the test group in comparison to the placebo group (p<0.005). The mean VSC scores were reduced from 292 to 172 ppb in the test group (p<0.005), whereas no reduction was observed in the placebo group. At the 2-week examination, the mean change of the VSC scores in the test group was significantly greater than the mean change in the placebo group (p<0.005). Neither in the test nor in the placebo group a significant reduction in tongue coating was observed.

CONCLUSIONS:

In conclusion, the tested mouthrinse is effective in the treatment of oral halitosis.

• Authors: E G Winkel, S Roldán, A J Van Winkelhoff, D Herrera, M Sanz
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 30 Issue 4 Pg. 300-6 (Apr 2003) ISSN: 0303-6979 [Print] United States
• PMID: 12694427 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Local
• Mouthwashes
• Placebos
• Sulfur Compounds
• Lactic Acid
• Cetylpyridinium
• Zinc
• Chlorhexidine

Topics

• Adult
• Aged
• Aged, 80 and over
• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Cetylpyridinium (administration & dosage, therapeutic use)
• Chlorhexidine (administration & dosage, therapeutic use)
• Double-Blind Method
• Female
• Follow-Up Studies
• Halitosis (drug therapy, metabolism, pathology)
• Humans
• Lactic Acid (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Mouthwashes (therapeutic use)
• Placebos
• Smell (physiology)
• Statistics, Nonparametric
• Sulfur Compounds (analysis)
• Tongue (pathology)
• Tooth Discoloration (chemically induced)
• Treatment Outcome
• Zinc (administration & dosage, therapeutic use)