Abstract | BACKGROUND: CASE PRESENTATION: We employed immunohistochemical analysis of decorin before and after UVA1 phototherapy. The skin specimens from three patients who were effectively treated with UVA1 phototherapy were analysed. Monoclonal antibody 6B6 as the specific reactivity to decorin was used. The increased decorin was focally accumulated in the newly synthesized collagen fibers in the sclerotic lesion of SSc. After UVA1 phototherapy, decorin was decreased in upper to middle dermis, although decorin was slightly increased in papillary dermis. CONCLUSIONS: These results suggest that decreased and normalized levels of accumulated decorin may relate to the efficacy of sclerotic lesions in UVA1 phototherapy.
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Authors | Hiroo Sawada, Zenzo Isogai, Akimichi Morita |
Journal | BMC dermatology
(BMC Dermatol)
Vol. 3
Pg. 2
(Mar 12 2003)
ISSN: 1471-5945 [Electronic] England |
PMID | 12689342
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DCN protein, human
- Decorin
- Extracellular Matrix Proteins
- Proteoglycans
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Topics |
- Aged
- Decorin
- Extracellular Matrix Proteins
- Female
- Humans
- Immunohistochemistry
- Middle Aged
- Proteoglycans
(analysis, metabolism)
- Scleroderma, Systemic
(metabolism, therapy)
- Ultraviolet Therapy
(methods)
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