Role of protein kinase C in the regulation of acetylcholine release in the central nervous system of spontaneously hypertensive rats.

Abstract	Previous studies have shown that the central cholinergic nervous system may be involved in blood pressure control. In the present study, we investigated the role of protein kinase C in the regulation of cholinergic nervous activity in the central nervous system in hypertension. In superfused slices of the striatum obtained from spontaneously hypertensive rats and age-matched Wistar-Kyoto rats, we examined the effects of the protein kinase C inhibitor H-7 on the release of [3H]-acetylcholine in vitro. The stimulation-evoked [3H]-acetylcholine release was not different between spontaneously hypertensive rats and Wistar-Kyoto rats. The protein kinase C inhibitor H-7 reduced the stimulation-evoked [3H]-acetylcholine release to a greater extent in spontaneously hypertensive rats than in Wistar-Kyoto rats. The results of the present study showed that the enhanced calcium-protein kinase C system might actively participate in the regulation of cholinergic nervous activity in the central nervous system in hypertension.
Authors	Kazushi Tsuda, Seiko Tsuda, Ichiro Nishio
Journal	Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 41 Suppl 1 Pg. S57-60 (Jan 2003) ISSN: 0160-2446 [Print] United States
PMID	12688398 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Calcium Channel Blockers Carrier Proteins Intracellular Signaling Peptides and Proteins protein kinase modulator Protein Kinase C Acetylcholine
Topics	Acetylcholine (metabolism) Animals Calcium Channel Blockers (pharmacology) Carrier Proteins (pharmacology) Central Nervous System (drug effects, enzymology, metabolism) Corpus Striatum (drug effects, metabolism) Hypertension (metabolism) In Vitro Techniques Intracellular Signaling Peptides and Proteins Male Protein Kinase C (antagonists & inhibitors, physiology) Rats Rats, Inbred SHR Rats, Inbred WKY

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