Abstract | BACKGROUND: METHODS: Adult mongrel dogs, weighing 9 to 13 kg, were allocated into five groups. FR167653 was continuously infused (FR-A (n = 7): 1 mg/kg/hr; FR-B (n = 6): 0.5 mg/kg/hr; FR-C (n = 6): 0.1 mg/kg/hr; FR-D (n = 5): 0.05 mg/kg/hr) from 30 minutes prior to ischemia to 2 hours after reperfusion. In the control group (n = 7), a vehicle was given continuously. Warm ischemia was induced for 3 hours. Arterial oxygen saturation (SaO2), left pulmonary vascular resistance (L-PVR), and cardiac output (CO) were measured. The lung was harvested for histologic study. RESULTS: SaO2 levels after 2 hours of reperfusion were significantly (p < 0.05) higher in groups FR-A, B, C, and D than in the control group. Just after reperfusion, CO deterioration was significantly (p < 0.05) greater in the control group than in the FR-treated groups, and the L-PVR level was significantly (p < 0.05) lower in groups FR-A, B, and C than in the control group. There were statistically significant differences (p < 0.05) in the survival rates of groups FR-A and B and the control group. Histological damage was more severe in the control group than in the FR-treated groups. CONCLUSION:
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Authors | H Ishikawa, I Takeyoshi, M Aiba, N Kamoshita, S Ohwada, K Matsumoto, Y Morishita |
Journal | International journal of surgical investigation
(Int J Surg Investig)
Vol. 2
Issue 3
Pg. 243-52
( 2000)
ISSN: 1028-5229 [Print] Switzerland |
PMID | 12678525
(Publication Type: Journal Article)
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Chemical References |
- FR 167653
- Immunosuppressive Agents
- Pyrazoles
- Pyridines
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Topics |
- Animals
- Blood Gas Analysis
- Disease Models, Animal
- Dogs
- Immunosuppressive Agents
(administration & dosage, therapeutic use)
- Lung
(pathology)
- Lung Transplantation
- Pyrazoles
(administration & dosage, therapeutic use)
- Pyridines
(administration & dosage, therapeutic use)
- Reperfusion Injury
(prevention & control)
- Survival Analysis
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