Abstract | OBJECTIVE: METHODS: RESULTS: In lean rats soy protein and flaxseed meal significantly decreased plasma total cholesterol (26.0% and 20.3% respectively) compared to casein. In obese rats flaxseed meal had significant cholesterol lowering effect compared to control rats (41%). Soy protein significantly lowered both plasma LDL-cholesterol and HDL-cholesterol in lean phenotypes while in obese phenotypes flaxseed meal significantly lowered LDL-cholesterol and HDL-cholesterol compared to casein-fed rats. Flaxseed meal also significantly lowered plasma triglyceride in both lean and obese rats compared to casein fed rats (33.7% and 37% respectively). There was significantly greater fat accumulation in livers of obese rats than lean rats (200%) regardless of dietary protein type. Flaxseed meal significantly lowered fat deposition in livers of both lean and obese rats compared to rats fed casein or soy protein. Dietary component(s) present in flaxseed meal or soy protein responsible for hypolipidemic effects is not clear. CONCLUSIONS: The marked hypotriglyceridemic and hypocholesterolemic effects of flaxseed meal may have important therapeutic implications in patients with hypertriglyceridemia and hypercholesterolemia and deserve further study in humans with these disorders. Flaxseed meal supplementation may provide a new therapeutic strategy to reduce hypertriglyceridemia and fatty liver.
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Authors | Sam J Bhathena, Ali A Ali, Christian Haudenschild, Patricia Latham, Tedine Ranich, Ali I Mohamed, Carl T Hansen, Manuel T Velasquez |
Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 22
Issue 2
Pg. 157-64
(Apr 2003)
ISSN: 0731-5724 [Print] United States |
PMID | 12672712
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Anticholesteremic Agents
- Caseins
- Cholesterol, HDL
- Cholesterol, LDL
- Soybean Proteins
- Triglycerides
- Cholesterol
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Topics |
- Animals
- Anticholesteremic Agents
(administration & dosage)
- Caseins
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Diabetes Mellitus, Type 2
(complications, therapy)
- Disease Models, Animal
- Fatty Liver
(blood, prevention & control)
- Flax
- Hypertriglyceridemia
(blood, prevention & control)
- Liver
(metabolism, pathology)
- Male
- Obesity
(complications, therapy)
- Rats
- Rats, Inbred SHR
- Soybean Proteins
(administration & dosage)
- Triglycerides
(blood)
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