Serum levels of endostatin and matrix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder.

Abstract

OBJECTIVES:

To analyze the preoperative serum levels of endostatin and matrix metalloproteinase-9 (MMP-9) in patients with primary transitional cell carcinoma of the bladder according to tumor stage and grade and to evaluate their clinical diagnostic application.

METHODS:

Preoperative serum levels of endostatin and MMP-9 were determined in 52 patients with transitional cell carcinoma of the bladder (13 with superficial carcinoma and 39 with advanced carcinoma) and 32 healthy controls by enzyme-linked immunosorbent assay.

RESULTS:

The serum levels of endostatin and MMP-9 were significantly greater in the 52 patients with bladder cancer than in the healthy controls (endostatin 46.8 ng/mL versus 30.6 ng/mL, P <0.001; MMP-9 786 ng/mL versus 417 ng/mL, P <0.001). The endostatin level correlated positively with the MMP-9 level (R = 0.55, P <0.01). Furthermore, the levels of endostatin and MMP-9 were associated with the tumor stage and grade. Patients with distant metastasis (n = 7) had significantly greater levels of endostatin and MMP-9 than patients without metastasis (n = 45) (endostatin 69.8 ng/mL versus 43.3 ng/mL, P <0.001; MMP-9 1529 ng/mL versus 674 ng/mL, P <0.001).

CONCLUSIONS:

Elevated endostatin and MMP-9 levels are associated with a greater stage and grade of primary transitional cell carcinoma of the bladder.

• Authors: Kao-Peng Guan, Hai-Yun Ye, Zheng Yan, Ying Wang, Shu-Kun Hou
• Journal: Urology (Urology) Vol. 61 Issue 4 Pg. 719-23 (Apr 2003) ISSN: 1527-9995 [Electronic] United States
• PMID: 12670552 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endostatins
• Peptide Fragments
• Collagen
• Matrix Metalloproteinase 9

Topics

• Carcinoma, Transitional Cell (blood, enzymology, pathology)
• Collagen (blood)
• Endostatins
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Matrix Metalloproteinase 9 (blood)
• Middle Aged
• Neoplasm Staging
• Peptide Fragments (blood)
• Urinary Bladder (pathology)
• Urinary Bladder Neoplasms (blood, enzymology, pathology)