[Association of hypersensitivity to wormwood pollen in patients with allergic rhinitis with HLA alleles polymorphism].

Abstract

OBJECTIVE:

Our purpose was to determine whether alleles at one or more HLA loci are associated with hypersensitivity to wormwood pollen in patients with allergic rhinitis.

METHOD:

By using PCR-SSP(sequence-specific primer polymerase chain reaction), we tested the frequency distribution of HLA-DQA1, DQB alleles in 41 patients with allergic rhinitis(AR) and 41 healthy controls from Beijing.

RESULT:

The frequency of HLA-DQA1* 0201, DQB1 * 0602 was lower in AR than in controls(24.39%, 4.88% vs 46.34%, 26.83%), and the frequency of DQA1 * 0302 was increased among patients(58.54% vs 14.63%).

CONCLUSION:

HLA-DQA1 * 0201, DQB1 * 0602 alleles might confer protection against AR, and DQA1 * 0302 may be a susceptibility factor for hypersensitivity to wormwood pollen.

• Authors: Zhimin Xing, Delin Yu, Shulan An
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 16 Issue 12 Pg. 678-80 (Dec 2002) China
• PMID: 12669444 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA-DQ Antigens
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• HLA-DQA1 antigen
• HLA-DQB1 antigen

Topics

• Adolescent
• Adult
• Aged
• Artemisia (immunology)
• Child
• Female
• HLA-DQ Antigens (genetics)
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• Humans
• Male
• Middle Aged
• Pollen (immunology)
• Rhinitis, Allergic, Perennial (etiology, genetics)