[A case of metastatic liver tumor of colorectal cancer responding to low-dose CPT-11 chemotherapy].

Abstract

We report a case in which low-dose CPT-11 chemotherapy was effective for metastatic liver tumor of sigmoid colon cancer. A 49-year-old male with metastatic liver tumor, who had undergone sigmoidectomy with D2 lymphadenectomy, was treated by low-dose CPT-11 chemotherapy (CPT-11 30 mg/m2 x 3 days, every 2 weeks). After 7 courses of this chemotherapy, CT and ultrasound examinations showed a reduction of tumor size in the liver. This chemotherapy also showed no high grade toxicities. Therefore, low-dose CPT-11 chemotherapy seems to be effective for metastatic colorectal cancer, and safe in view of toxicities.

• Authors: Kimihiko Funahashi, Toshitsugu Miki, Junichi Koike, Naohiro Washizawa, Yumiko Shibata, Hiroshi Matsumoto, Takayuki Tokuyama, Masamine Ryu, Hiroyuki Shiokawa, Tomohiko Goto, Tatsuo Teramoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 30 Issue 3 Pg. 419-21 (Mar 2003) ISSN: 0385-0684 [Print] Japan
• PMID: 12669404 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Irinotecan
• Camptothecin

Topics

• Adenocarcinoma (drug therapy, secondary)
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Camptothecin (administration & dosage, analogs & derivatives)
• Colorectal Neoplasms (drug therapy, secondary)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Humans
• Irinotecan
• Liver Neoplasms (drug therapy, secondary)
• Male
• Middle Aged