Abstract |
A common polymorphism (C825T) of the gene encoding the G-protein beta(3) subunit has been associated with obesity. We examined the hypothesis that this polymorphism affected weight gain during pregnancy. Two hundred and ninety-four women with uncomplicated term deliveries of singleton pregnancies were genotyped. Women homozygous for the T allele (TT) gained significantly more weight than women carrying the C allele (CC and CT groups) (P = 0.006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.
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Authors | Victor Dishy, Simi Gupta, Ruth Landau, Hong-Guang Xie, Richard B Kim, Richard M Smiley, Daniel W Byrne, Alastair J J Wood, C Michael Stein |
Journal | Pharmacogenetics
(Pharmacogenetics)
Vol. 13
Issue 4
Pg. 241-2
(Apr 2003)
ISSN: 0960-314X [Print] England |
PMID | 12668921
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- G-protein beta3 subunit
- Heterotrimeric GTP-Binding Proteins
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Topics |
- Adult
- Birth Weight
- Female
- Heterotrimeric GTP-Binding Proteins
(genetics)
- Humans
- Infant, Newborn
- Polymorphism, Single Nucleotide
- Pregnancy
(genetics, physiology)
- Weight Gain
(genetics)
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