Abstract | BACKGROUND: METHODS: Ninety-eight ARDS patients received either the experimental or control diet (minimum of 75% of basal energy expenditure x 1.3) for at least 4 to 7 days. Total radical antioxidant potential (TRAP), lipid peroxide levels (LPO), and plasma antioxidant concentrations were determined at baseline and study days 4 and 7. Sixty-two normal individuals were assessed for reference values. RESULTS: At baseline, ARDS patients had significantly lower plasma beta-carotene, retinol, and alpha-tocopherol, lower TRAP, and higher LPO values compared with normals. After 4 days of feeding, beta-carotene and alpha-tocopherol levels were normalized and significantly increased in the experimental group compared with controls. TRAP and LPO were not significantly different between groups and study day 4 and 7 values were not different from baseline values. Retinol levels increased equally in both groups. CONCLUSIONS: Before treatment, ARDS patients were found to be in a state of oxidative stress and had reduced levels of antioxidants. Although enteral nutrition with the experimental diet for at least 4 to 7 days did not reduce oxidative stress as measured, it did restore plasma levels of beta-carotene and alpha-tocopherol to normal or higher levels and appeared to protect ARDS patients from further lipid peroxidation.
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Authors | Jeffrey L Nelson, Stephen J DeMichele, Eric R Pacht, Ann K Wennberg, Enteral Nutrition in ARDS Study Group |
Journal | JPEN. Journal of parenteral and enteral nutrition
(JPEN J Parenter Enteral Nutr)
2003 Mar-Apr
Vol. 27
Issue 2
Pg. 98-104
ISSN: 0148-6071 [Print] United States |
PMID | 12665164
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- beta Carotene
- gamma-Linolenic Acid
- Eicosapentaenoic Acid
- alpha-Tocopherol
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Topics |
- Adult
- Antioxidants
(administration & dosage, metabolism)
- Double-Blind Method
- Eicosapentaenoic Acid
(administration & dosage)
- Enteral Nutrition
- Humans
- Lipid Peroxidation
(drug effects)
- Oxidation-Reduction
- Oxidative Stress
- Respiratory Distress Syndrome
(blood, metabolism, therapy)
- alpha-Tocopherol
(blood)
- beta Carotene
(blood)
- gamma-Linolenic Acid
(administration & dosage)
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