Successful therapy of tardive dyskinesia in a 71-year-old woman with a combination of tetrabenazine, olanzapine and tiapride.

There is no generally accepted treatment for tardive dyskinesia following intake of neuroleptics. Many compounds with effects on serotonine, GABA, cholinergic or dopamine receptors have been clinically useful. We report on a 71-year-old female patient suffering from orofacial tardive dyskinesia after treatment with haloperidol, which did not respond to monotherapy with antidyskinetic drugs. The syndrome disappeared almost completely within two weeks after a multidrug approach consisting of tetrabenazine, olanzapine and tiapride. A combination of antidyskinetic drugs should be considered in patients with severe tardive dyskinesia.
AuthorsH J Koch, A Szecsey, M Vogel, D Fischer-Barnicol
JournalInternational journal of clinical practice (Int J Clin Pract) Vol. 57 Issue 2 Pg. 147-9 (Mar 2003) ISSN: 1368-5031 [Print] India
PMID12661802 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Dyskinesia Agents
  • Antipsychotic Agents
  • Benzodiazepines
  • Pirenzepine
  • Haloperidol
  • Olanzapine
  • Tiapamil Hydrochloride
  • Tetrabenazine
  • Aged
  • Anti-Dyskinesia Agents (adverse effects, therapeutic use)
  • Antipsychotic Agents (adverse effects, therapeutic use)
  • Benzodiazepines
  • Drug Therapy, Combination
  • Dyskinesia, Drug-Induced (drug therapy, etiology)
  • Female
  • Haloperidol (adverse effects)
  • Humans
  • Olanzapine
  • Pirenzepine (analogs & derivatives, therapeutic use)
  • Tetrabenazine (therapeutic use)
  • Tiapamil Hydrochloride (therapeutic use)
  • Treatment Outcome

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