Abstract |
Attention-deficit hyperactivity disorder ( ADHD) is the most common childhood psychiatric disorder, affecting 5-10% of school-age children. Although the biological basis of this disorder is unknown, twin and family studies provide strong evidence that ADHD has a genetic basis involving multiple genes. A previous study found an association between ADHD and two polymorphisms in the 3' untranslated region (UTR) of SNAP-25, a gene encoding a synaptic vesicle docking protein known to play a role in the hyperactivity observed in the Coloboma mouse strain. In this paper, we test biased transmission of the 3' UTR SNAP-25 haplotype using a larger ADHD sample of 113 families with 207 affected children. Using the transmission disequilibrium test (TDT), we found a trend consistent with biased transmission of the TC haplotype of SNAP-25 in all transmissions and detected a significant distortion (P=0.027) when paternal transmissions were evaluated.
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Authors | V Kustanovich, B Merriman, J McGough, J T McCracken, S L Smalley, S F Nelson |
Journal | Molecular psychiatry
(Mol Psychiatry)
Vol. 8
Issue 3
Pg. 309-15
(Mar 2003)
ISSN: 1359-4184 [Print] England |
PMID | 12660803
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Membrane Proteins
- Nerve Tissue Proteins
- SNAP25 protein, human
- Synaptosomal-Associated Protein 25
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Topics |
- Adolescent
- Attention Deficit Disorder with Hyperactivity
(epidemiology, genetics)
- Child
- Fathers
- Female
- Gene Frequency
- Genetic Predisposition to Disease
(epidemiology, genetics)
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Membrane Proteins
(genetics)
- Nerve Tissue Proteins
(genetics)
- Risk Factors
- Sample Size
- Synaptosomal-Associated Protein 25
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