Abstract | OBJECTIVE: DATA SOURCES: Searches of MEDLINE (1966-July 2002), Cochrane Library, International Pharmaceutical Abstracts (1977-July 2002), and an extensive manual review of journals were performed using the key search terms calcitonin, analgesic, osteoporosis, vertebral fracture, and pain. STUDY SELECTION AND DATA EXTRACTION: All articles identified from the data sources were evaluated and all information deemed relevant was included for this review. DATA SYNTHESIS: Fractures, especially vertebral fractures, are a common complication of osteoporosis, leading to significant pain. Calcitonin has been studied for its analgesic properties. Fourteen double-blind, placebo-controlled trials that evaluated the analgesic efficacy of calcitonin for osteoporosis-related vertebral fracture pain were identified and reviewed. Thirteen of these studies demonstrated statistically significant improvement in pain or function in calcitonin-treated patients. CONCLUSIONS:
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Authors | Linsey A Blau, James D Hoehns |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 37
Issue 4
Pg. 564-70
(Apr 2003)
ISSN: 1060-0280 [Print] United States |
PMID | 12659616
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Analgesics
(administration & dosage, pharmacology, therapeutic use)
- Calcitonin
(administration & dosage, pharmacology, therapeutic use)
- Controlled Clinical Trials as Topic
- Humans
- Pain
(complications, drug therapy)
- Spinal Fractures
(complications)
- Spine
(drug effects, pathology)
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