Abstract |
We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Combination therapy that used suboptimal FK with amphotericin B or itraconazole prolonged survival. Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone.
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Authors | Javier Capilla Luque, Karl V Clemons, David A Stevens |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 47
Issue 4
Pg. 1452-5
(Apr 2003)
ISSN: 0066-4804 [Print] United States |
PMID | 12654692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Echinocandins
- Lipopeptides
- Lipoproteins
- Peptides, Cyclic
- Itraconazole
- Amphotericin B
- Micafungin
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Topics |
- Amphotericin B
(administration & dosage)
- Animals
- Antifungal Agents
(therapeutic use)
- Aspergillosis
(drug therapy)
- Drug Therapy, Combination
- Echinocandins
- Female
- Itraconazole
(administration & dosage)
- Lipopeptides
- Lipoproteins
(administration & dosage, therapeutic use)
- Micafungin
- Peptides, Cyclic
(administration & dosage, therapeutic use)
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