Abstract |
Seventeen patients with therapy-related myelodysplastic syndrome/acute myeloid leukaemia (t-MDS/AML) were examined for aberrant p15 gene methylation by methylation-specific polymerase chain reaction. Ten patients (58%) showed p15 methylation, which was significantly related to monosomy/deletion of chromosome 7q, but not to antecedent chemotherapy, blast count, leukaemic evolution or survival. In three of six patients with marrow samples obtained prior to the diagnosis of t-MDS/AML, p15 methylation predated disease development by up to 2 years. Bone marrow transplantation led to the disappearance of p15 methylation in one patient. These results showed that p15 methylation was an early event in the evolution of some t-MDS/AML patients.
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Authors | W Y Au, A Fung, C Man, S K Ma, T S Wan, R Liang, Y L Kwong |
Journal | British journal of haematology
(Br J Haematol)
Vol. 120
Issue 6
Pg. 1062-5
(Mar 2003)
ISSN: 0007-1048 [Print] England |
PMID | 12648079
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CDKN2B protein, human
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p15
- Transcription Factors
- Tumor Suppressor Proteins
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Topics |
- Acute Disease
- Adult
- Aged
- Bone Marrow Transplantation
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p15
- DNA Methylation
- Female
- Humans
- Leukemia, Myeloid
(genetics, metabolism, therapy)
- Male
- Middle Aged
- Myelodysplastic Syndromes
(genetics, metabolism, therapy)
- Polymerase Chain Reaction
(methods)
- Promoter Regions, Genetic
- Time Factors
- Transcription Factors
(genetics)
- Tumor Suppressor Proteins
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