HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations.

Abstract
Seventeen patients with therapy-related myelodysplastic syndrome/acute myeloid leukaemia (t-MDS/AML) were examined for aberrant p15 gene methylation by methylation-specific polymerase chain reaction. Ten patients (58%) showed p15 methylation, which was significantly related to monosomy/deletion of chromosome 7q, but not to antecedent chemotherapy, blast count, leukaemic evolution or survival. In three of six patients with marrow samples obtained prior to the diagnosis of t-MDS/AML, p15 methylation predated disease development by up to 2 years. Bone marrow transplantation led to the disappearance of p15 methylation in one patient. These results showed that p15 methylation was an early event in the evolution of some t-MDS/AML patients.
AuthorsW Y Au, A Fung, C Man, S K Ma, T S Wan, R Liang, Y L Kwong
JournalBritish journal of haematology (Br J Haematol) Vol. 120 Issue 6 Pg. 1062-5 (Mar 2003) ISSN: 0007-1048 [Print] England
PMID12648079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CDKN2B protein, human
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p15
  • Transcription Factors
  • Tumor Suppressor Proteins
Topics
  • Acute Disease
  • Adult
  • Aged
  • Bone Marrow Transplantation
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p15
  • DNA Methylation
  • Female
  • Humans
  • Leukemia, Myeloid (genetics, metabolism, therapy)
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes (genetics, metabolism, therapy)
  • Polymerase Chain Reaction (methods)
  • Promoter Regions, Genetic
  • Time Factors
  • Transcription Factors (genetics)
  • Tumor Suppressor Proteins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: