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New advances and novel treatments in heart failure.

Abstract
As briefly summarized in this report, the prevalence of heart failure is high and it will continue to rise as the population ages. There will be over 1 million hospitalizations for acutely decompensated heart failure this year. The goals of treatment for patients with acutely decompensated heart failure are to lower cardiac filling pressures, remove fluids and improve symptoms of dyspnea, decrease vascular resistance, and increase cardiac output without activating the RAAS. There are few guidelines for the treatment of individuals with acutely decompensated heart failure and many different agents have been used in patients with this disease. Many of these drugs are not completely effective and may lead to serious adverse events. BNP is a natural protein produced by myocardial cells in response to ventricular distension, and its level is dramatically increased in patients with heart failure. The results of several recent clinical trials have shown that administration of nesiritide is safe and highly effective for the initial treatment of patients with acutely decompensated heart failure and can help physicians and nurses meet treatment goals for the management of patients with this serious condition.
AuthorsAndrew Lee Smith, Carolyn S Brown
JournalCritical care nurse (Crit Care Nurse) Vol. Suppl Pg. 11-8; quiz 19-20 (Feb 2003) ISSN: 0279-5442 [Print] United States
PMID12640965 (Publication Type: Journal Article, Review)
Chemical References
  • Natriuretic Agents
  • Natriuretic Peptide, Brain
Topics
  • Acute Disease
  • Heart Failure (blood, diagnosis, drug therapy, physiopathology)
  • Humans
  • Natriuretic Agents (blood, therapeutic use)
  • Natriuretic Peptide, Brain

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