Long-term outcome in children with Guillain-Barré syndrome.

Abstract

OBJECTIVE:

To determine the long-term sequelae and early predictors of sequelae for children with Guillain-Barré syndrome (GBS) after the introduction of intravenous gammaglobulin (IVIG). Study design A cross-sectional case series of children with GBS, at least 2 years after recovery, was performed. Manual muscle strength testing was done on 34 muscle groups. The functional independence measure was used to assess function. A chart review was completed, identifying acute factors that may predict long-term sequelae.

RESULTS:

Forty-seven children with GBS were identified, of whom 30 received IVIG. Persisting long-term muscle weakness with at least one muscle group at a grade 6 level (muscle moves the joint against gravity but only minimal resistance to an applied force) was found in 23% of cases. Each patient had a perfect score on the functional independence measure. Long-term muscle weakness was predicted by young age (P =.03) and a rapid progression to maximal weakness (P =.03).

CONCLUSIONS:

Despite the introduction of IVIG, 23% of children with GBS had evidence of long-term mild muscle weakness, with minimal impact on function. Young age and a rapid progression during the acute GBS period predicted long-term sequelae.

• Authors: Jiri Vajsar, Darcy Fehlings, Derek Stephens
• Journal: The Journal of pediatrics (J Pediatr) Vol. 142 Issue 3 Pg. 305-9 (Mar 2003) ISSN: 0022-3476 [Print] United States
• PMID: 12640380 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Activities of Daily Living
• Adolescent
• Child
• Child, Preschool
• Cross-Sectional Studies
• Female
• Follow-Up Studies
• Guillain-Barre Syndrome (complications, therapy)
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Male
• Muscle Contraction
• Muscle Weakness (diagnosis, etiology)
• Prognosis
• Risk Factors