Abstract | BACKGROUND: Recipients of organ transplant who are immunosuppressed are at greatly increased risk of nonmelanoma skin cancers compared with the general population, but their risk of appendageal tumors is unknown. OBJECTIVE: Our aim was to conduct a systematic examination of cutaneous appendageal tumors arising in recipients of organ transplants compared with individuals who were immunocompetent (ICP). METHODS: We conducted a retrospective, clinicopathologic analysis of consecutive appendageal tumors arising in 650 recipients of organ transplants and in the general population of approximately 605,000 people served by our institution. RESULTS: Between 1993 and 1998, 231 appendageal tumors were identified in 211 individuals; 23 tumors were found in 21 of 650 patients undergoing transplant (3%), 10 in individuals with other immunosuppressive conditions, 3 in 2 patients with Muir-Torre syndrome, and 195 in 178 apparently ICP. In addition to the increased frequency of appendageal tumors among recipients of transplants, malignant tumors were overrepresented (43% of transplant tumors vs 4% in ICP; P <.0001) as were tumors of sebaceous origin (30% vs 6%; P <.0001). CONCLUSIONS: Recipients of organ transplant who are immunosuppressed have a greatly increased risk of cutaneous appendageal tumors compared with apparently ICP. In addition, their tumors are more likely to be malignant and of sebaceous origin.
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Authors | Catherine A Harwood, Jane M McGregor, Victoria J Swale, Charlotte M Proby, Irene M Leigh, Robert Newton, S Mohsen Khorshid, Rino Cerio |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 48
Issue 3
Pg. 401-8
(Mar 2003)
ISSN: 0190-9622 [Print] United States |
PMID | 12637920
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Age Distribution
- Aged
- Aged, 80 and over
- Biopsy, Needle
- Carcinoma, Skin Appendage
(epidemiology, immunology, pathology)
- Case-Control Studies
- Female
- Follow-Up Studies
- Graft Rejection
- Graft Survival
- Humans
- Immunocompromised Host
(immunology)
- Immunohistochemistry
- Incidence
- Male
- Middle Aged
- Organ Transplantation
(adverse effects)
- Reference Values
- Retrospective Studies
- Risk Assessment
- Sex Distribution
- Skin Neoplasms
(epidemiology, immunology, pathology)
- Transplantation Immunology
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