Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.

Abstract

The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.

• Authors: Sallie R Permar, Sherry A Klumpp, Keith G Mansfield, Woong-Ki Kim, Darci A Gorgone, Michelle A Lifton, Kenneth C Williams, Jörn E Schmitz, Keith A Reimann, Michael K Axthelm, Fernando P Polack, Diane E Griffin, Norman L Letvin
• Journal: Journal of virology (J Virol) Vol. 77 Issue 7 Pg. 4396-400 (Apr 2003) ISSN: 0022-538X [Print] United States
• PMID: 12634396 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA, Viral
• Measles Vaccine
• RNA, Viral

Topics

• Animals
• Base Sequence
• CD8-Positive T-Lymphocytes (immunology, pathology)
• DNA, Viral (genetics)
• Disease Models, Animal
• Humans
• Immunity, Cellular
• Lymphocyte Depletion
• Macaca mulatta
• Measles (immunology, pathology, virology)
• Measles Vaccine (immunology)
• Measles virus (immunology, pathogenicity, physiology)
• RNA, Viral (genetics, metabolism)
• Virus Replication (immunology)