Abstract |
Estramustine phosphate has been useful in the treatment of advanced carcinoma of the prostate. Objective remissions were obtained with this therapy in 6 of 17 patients (35 per cent). The results presented herein indicate that the clinical response is to a certain extent caused by an estrogen effect, which was clearly demonstrable in a previously untreated patient. A specific cytostatic effect of estramustine phosphate, which is not yet clearly explained, may be responsible for remissions in some patients who have become resistant to conventional hormonal treatment.
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Authors | S D Fosså, A Miller |
Journal | The Journal of urology
(J Urol)
Vol. 115
Issue 4
Pg. 406-8
(Apr 1976)
ISSN: 0022-5347 [Print] United States |
PMID | 1263316
(Publication Type: Journal Article)
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Chemical References |
- Estrogens
- Nitrogen Mustard Compounds
- Estramustine
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Topics |
- Aged
- Castration
- Estramustine
(adverse effects, therapeutic use)
- Estrogens
(therapeutic use)
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- Nitrogen Mustard Compounds
(therapeutic use)
- Prostatic Neoplasms
(drug therapy, surgery)
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