HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Repeat retroperitoneal lymph node dissection for metastatic testis cancer.

AbstractPURPOSE:
We report pathological results, perioperative complications and patient outcome in 21 men after repeat retroperitoneal lymph node dissection for metastatic testis cancer.
MATERIALS AND METHODS:
We reviewed an institutional tumor registry at our cancer center and identified 417 patients who underwent retroperitoneal lymph node dissection for testis cancer during a 21-year period. Of these 417 patients 21 underwent repeat retroperitoneal lymph node dissection. We reviewed preoperative patient characteristics, operative data and pathological findings from repeat lymphadenectomy, and determined patient disease status, morbidity and mortality after surgery.
RESULTS:
We identified viable germ cell tumor in 5 patients (24%), teratoma in 14 (67%) and fibrosis or necrosis only in 5 (24%). Intraoperatively subadventitial dissection of the aorta occurred in 2 cases, which was severe enough in 1 to require an aortic graft. The most common postoperative complications were prolonged ileus or partial bowel obstruction and chylous ascites in 6 and 3 patients, respectively. Six patients died, including 5 of disease progression and 1 of postoperative pulmonary embolus. At a mean followup of 4.7 years (range 0.1 to 14) 15 patients (71%) were alive and 14 (67%) were disease-free.
CONCLUSIONS:
Repeat retroperitoneal lymph node dissection is safe and effective in the majority of patients with recurrent or residual retroperitoneal masses after initial multimodality treatments for metastatic testis cancer. Overall perioperative morbidity and mortality are low and yet the potential for significant vascular complications warrants careful preoperative planning and intraoperative judgment.
AuthorsWade J Sexton, Christopher G Wood, Richard Kim, Louis L Pisters
JournalThe Journal of urology (J Urol) Vol. 169 Issue 4 Pg. 1353-6 (Apr 2003) ISSN: 0022-5347 [Print] United States
PMID12629359 (Publication Type: Journal Article)
Topics
  • Adolescent
  • Adult
  • Disease-Free Survival
  • Follow-Up Studies
  • Humans
  • Lymph Node Excision (methods)
  • Lymph Nodes (pathology)
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (mortality, pathology, surgery)
  • Neoplasm, Residual (mortality, pathology, surgery)
  • Postoperative Complications (etiology, mortality)
  • Reoperation
  • Retroperitoneal Neoplasms (mortality, pathology, secondary, surgery)
  • Retroperitoneal Space
  • Testicular Neoplasms (mortality, pathology, surgery)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: