Abstract | OBJECTIVE: DESIGN: Prospective clinical study. SETTING: A University Cardiothoracic Intensive Care Unit. METHODS: Levels of cytokines (IL-6, IL-8, IL-10, IL-18, and TGF- ) and procalcitonin (PCT) were measured at the first four postoperative days in 16 adult male patients with an Apache II-score >24 and two or more organ dysfunctions after myocardial revascularization. MAIN RESULTS: All pro-inflammatory cytokines, except for IL-6, were significantly elevated in non-survivors from MODS, with peak values at the first two postoperative days. The plasma levels of immunoinhibitory cytokines showed no differences between the groups. CONCLUSIONS: The results of our study show a different expression of pro-inflammatory cytokines in survivors and non-survivors from MODS following operations with extracorporeal circulation. In addition to Apache-II score, especially IL-8, IL-18, and PCT may be used as parameters for the prognosis of patients with organ dysfunctions after cardiac surgery.
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Authors | A Sablotzki, M G Dehne, I Friedrich, S Grond, B Zickmann, J Mühling, R E Silber, E G Czeslick |
Journal | European journal of medical research
(Eur J Med Res)
Vol. 8
Issue 2
Pg. 71-6
(Feb 21 2003)
ISSN: 0949-2321 [Print] England |
PMID | 12626284
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- CALCA protein, human
- Cytokines
- Protein Precursors
- Calcitonin
- Calcitonin Gene-Related Peptide
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Topics |
- APACHE
- Aged
- Calcitonin
(blood)
- Calcitonin Gene-Related Peptide
- Cardiopulmonary Bypass
(adverse effects)
- Cytokines
(blood)
- Hospitals, University
- Humans
- Male
- Multiple Organ Failure
(blood, complications, mortality)
- Myocardial Revascularization
(adverse effects, mortality)
- Postoperative Complications
(blood, mortality)
- Prospective Studies
- Protein Precursors
(blood)
- Survival Rate
- Systemic Inflammatory Response Syndrome
(blood, etiology, mortality)
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