[Investigation on administration method of carbapenems].

Abstract

Seventy-two women diagnosed as parametritis were enrolled in this study and examined on the effective administration method of carbapenems, imipenem/cilastatin (IPM/CS), panipenem/betamipron (PAPM/BP) and meropenem (MEPM). The total dosage of each carbapenem was 1.5 g/day, and administration frequency was twice a day (0.75 g x 2) or three times a day (0.5 g x 3). We reviewed the highest body temperature, white blood cell count and CRP value, before treatment and the fourth day after the start of treatment. Three times a day method was statistically superior to twice a day method in the highest body temperature, and CRP value. When we use carbapenem antimicrobial agents, the basis of PK/PD of time above MIC would lead to the increasing clinical effects.

• Authors: Hiroshige Mikamo, Mochiyoshi Ninomiya, Teruhiko Tamaya
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 55 Issue 6 Pg. 875-81 (Dec 2002) ISSN: 0368-2781 [Print] Japan
• PMID: 12621741 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Carbapenems
• Drug Combinations
• Thienamycins
• beta-Alanine
• panipenem-betamipron
• Cilastatin
• Imipenem
• C-Reactive Protein
• Cilastatin, Imipenem Drug Combination
• Meropenem

Topics

• Adult
• Aged
• Body Temperature
• C-Reactive Protein
• Carbapenems (administration & dosage, pharmacokinetics)
• Cilastatin (administration & dosage, pharmacokinetics)
• Cilastatin, Imipenem Drug Combination
• Drug Administration Schedule
• Drug Combinations
• Female
• Humans
• Imipenem (administration & dosage, pharmacokinetics)
• Leukocyte Count
• Meropenem
• Middle Aged
• Parametritis (drug therapy, physiopathology)
• Thienamycins (administration & dosage, pharmacokinetics)
• beta-Alanine (administration & dosage, analogs & derivatives, pharmacokinetics)