[Evaluation of clarithromycin efficacy in the treatment of community-acquired pneumonia on the basis of the Binax NOW test results (a prospective open trial)].

Abstract

The results of the treatment of community-acquired pneumonia with clarithromycin (500 mg bid for 6-8 days) at 172 patients (military recruits aged 18-25) are presented. Diagnosis, infection performance, treatment efficacy were evaluated by complex of data (X-ray, sputum analysis by bacteriological and cultural tests and immunochromatography test Binax NOW for pneumococcal antigen identification). High efficacy of clarithromycin for the treatment of moderate and mild pneumonia (including pneumococcal pneumonia) was demonstrated. Side effects were registered at 6.2 per cent of patients (gastro-intestinal disorders at 5 patients) and 1 general urticaria at 1 patient whose treatment had to be changed).

• Authors: I A Guchev, O I Klochkov, V A Ul'ianov
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 47 Issue 9 Pg. 18-21 ( 2002) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Otsenka éffektivnosti klaritromitsina pri terapii vnebol'nichnykh pnevmoniĭ, osnovannoĭ na rezul'tatakh testa Binax NOW (otkrytoe prospektivnoe issledovanie).
• PMID: 12619516 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antigens, Bacterial
• Reagent Kits, Diagnostic
• Clarithromycin

Topics

• Adolescent
• Adult
• Anti-Bacterial Agents (therapeutic use)
• Antigens, Bacterial (analysis)
• Chromatography (methods)
• Clarithromycin (adverse effects, therapeutic use)
• Community-Acquired Infections (diagnosis, drug therapy)
• Gastrointestinal Diseases (chemically induced)
• Humans
• Immunologic Techniques
• Male
• Military Personnel
• Pneumonia, Pneumococcal (diagnosis, drug therapy)
• Prospective Studies
• Reagent Kits, Diagnostic
• Sputum (microbiology)
• Streptococcus pneumoniae (immunology, isolation & purification)
• Urticaria (chemically induced)