Abstract |
Daily urinary catecholamine excretion ( DOPA, DA, DOPAC, NA, A) was studied in 66 patients with Parkinson's disease, 38 of them with differently expressed depression. Depression severity correlated with rigid form of disorders (p < 0.001). Biochemical profile of the depressive patients was characterized by noradrenaline (NA) to adrenaline (A) ratio reduction (p < 0.01) and dopamine to NA (p < 0.01) ratio increase on the background of total catecholamines deficit. Changes of NA/A and DOPA and correlation between DOPA and depression severity imply a role of dopamine neuromediator deficit in depression development.
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Authors | M V Selikhova, B M Kogan, I L Ustinova |
Journal | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
(Zh Nevrol Psikhiatr Im S S Korsakova)
Vol. 103
Issue 1
Pg. 39-42
( 2003)
ISSN: 1997-7298 [Print] Russia (Federation) |
Vernacular Title | Obmen katekhomaminov pri bolezni Parkinsona s depressieĭ. |
PMID | 12616737
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Catecholamines
(metabolism)
- Depressive Disorder, Major
(diagnosis, etiology, psychology)
- Female
- Humans
- Male
- Middle Aged
- Parkinson Disease
(metabolism, psychology)
- Severity of Illness Index
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