Olanzapine treatment of anorexia nervosa: a retrospective study.

Abstract

BACKGROUND:

Recent reports raise the possibility that olanzapine, which commonly causes weight gain in non-eating-disordered subjects, assisted weight gain and mood during refeeding in anorexia nervosa (AN) patients.

METHODS:

Eighteen AN subjects who engaged in open treatment with olanzapine were retrospectively questioned about their response.

RESULTS:

Subjects reported a significant reduction in anxiety, difficulty eating, and core eating disorder symptoms after taking olanzapine.

DISCUSSION:

These data lend support to the possibility that olanzapine may be useful in AN patients.

CONCLUSION:

A controlled trial is necessary to prove that olanzapine is efficacious.

• Authors: Amanda Malina, Jill Gaskill, Claire McConaha, Guido K Frank, Maria LaVia, Lisa Scholar, Walter H Kaye
• Journal: The International journal of eating disorders (Int J Eat Disord) Vol. 33 Issue 2 Pg. 234-7 (Mar 2003) ISSN: 0276-3478 [Print] United States
• PMID: 12616591 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 by Wiley Periodicals, Inc.

Chemical References

• Serotonin Uptake Inhibitors
• Benzodiazepines
• Pirenzepine
• Olanzapine

Topics

• Adolescent
• Adult
• Anorexia Nervosa (diagnosis, drug therapy)
• Benzodiazepines
• Humans
• Olanzapine
• Pirenzepine (analogs & derivatives, therapeutic use)
• Retrospective Studies
• Selective Serotonin Reuptake Inhibitors (therapeutic use)
• Surveys and Questionnaires