Retinal capillary hemangioma treatment by indocyanine green-mediated photothrombosis.

Abstract

PURPOSE:

To describe the clinical, angiographic and optical coherence tomography (OCT) findings of a patient with a large retinal capillary hemangioma who was treated by indocyanine green-mediated photothrombosis. Interventional case report.

METHODS:

An 18-year-old male patient was treated at a tertiary referral center with a novel laser-dye procedure that uses low-irradiance 810-nm laser and intravenous indocyanine green injection and was prospectively evaluated with fluorescein and indocyanine green angiography, as well as OCT.

RESULTS:

Vision improved from 20/125 to 20/32 + 1 at 1-year follow-up. Fundus photography showed marked reduction of a 3 disk diameters retinal capillary hemangioma. Both fluorescein and indocyanine green angiography demonstrated reduced tumor perfusion and narrowing of the lesion feeder and draining vessels as early as 5 days after indocyanine green-mediated photothrombosis; OCT showed immediate decrease in retinal elevation and complete resolution of subretinal fluid within 2 months of treatment. Minimal laser-induced effects were noted in the vicinity of the tumor.

CONCLUSIONS:

Photothrombosis using low-intensity, 810-nm light to direct laser energy continuously at the tumor after intravenous indocyanine green infusion was effective in restoring macular architecture and improving vision in a patient with a large peripheral retinal capillary hemangioma by means of substantial occlusion of the tumor vasculature and resolution of subretinal fluid.

• Authors: Rogério A Costa, Rodrigo L Meirelles, José A Cardillo, Marcelo L Abrantes, Michel E Farah
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 135 Issue 3 Pg. 395-8 (Mar 2003) ISSN: 0002-9394 [Print] United States
• PMID: 12614766 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2003 by Elsevier Science Inc.

Chemical References

• Coloring Agents
• Indocyanine Green

Topics

• Adolescent
• Coloring Agents (therapeutic use)
• Fluorescein Angiography
• Hemangioma, Capillary (blood supply, drug therapy, pathology)
• Humans
• Indocyanine Green (therapeutic use)
• Interferometry
• Light
• Male
• Photochemotherapy
• Prospective Studies
• Retinal Neoplasms (blood supply, drug therapy, pathology)
• Retinal Vessels (drug effects, pathology)
• Thrombosis (etiology)
• Tomography
• Visual Acuity