Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults.

This randomized, double-blind, controlled trial evaluated the influence of low fat, low saturated fat food products that contained free tall oil-based phytosterols (TOP) and oat beta-glucan (from whole oats and bran concentrate) on serum lipid concentrations in adults with mild-to-moderate hypercholesterolemia. After a 5-wk National Cholesterol Education Program Step I diet lead-in period, 112 subjects incorporated one of two treatments into their diets for 6 wk: food products (cereal, snack bar and beverage) that provided 1.8 g TOP and 2.8 g beta-glucan/d and contained < or =3.0 g total fat and < or =1.0 g saturated fat (TOP/beta-glucan treatment) or similar control foods. The serum LDL cholesterol response from baseline to the end of study was significantly larger in the TOP/beta-glucan treated group than in the control group, in which there was no change (-3.7 vs. 0.4%; P = 0.013). Likewise, total cholesterol decreased in the TOP/beta-glucan treatment group and did not change significantly in the controls (-2.3 vs. 0.8%; P = 0.043). Serum HDL cholesterol and triglyceride responses did not differ between the groups. The results of this trial suggest that consumption of a group of low fat, TOP and beta-glucan- containing foods is a useful adjunct in the dietary management of hypercholesterolemia.
AuthorsKevin C Maki, Fred Shinnick, Marlyn A Seeley, Patricia E Veith, Laura C Quinn, Pamela J Hallissey, Arlene Temer, Michael H Davidson
JournalThe Journal of nutrition (J Nutr) Vol. 133 Issue 3 Pg. 808-13 (Mar 2003) ISSN: 0022-3166 [Print] United States
PMID12612157 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Cholesterol, Dietary
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Dietary Fats
  • Dietary Fiber
  • Glucans
  • Phytosterols
  • Triglycerides
  • Cholesterol
  • Adult
  • Aged
  • Avena (chemistry)
  • Cholesterol (blood)
  • Cholesterol, Dietary (administration & dosage)
  • Cholesterol, HDL (blood)
  • Cholesterol, LDL (blood)
  • Diet
  • Diet Records
  • Dietary Fats (administration & dosage)
  • Dietary Fiber (administration & dosage)
  • Double-Blind Method
  • Female
  • Glucans (administration & dosage, adverse effects)
  • Humans
  • Hypercholesterolemia (blood, diet therapy)
  • Male
  • Middle Aged
  • Phytosterols (administration & dosage, adverse effects)
  • Triglycerides (blood)

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