Abstract | BACKGROUND: METHODS: Male Wistar rats were divided into 3 groups: a group that underwent hydrochloric acid aspiration and mechanical gas ventilation (ALI group, n = 15), a group that underwent acid aspiration and partial liquid ventilation beginning 90 minutes after acid aspiration (PLV group, n = 15), and a group that underwent mechanical ventilation without acid aspiration (control group, n = 5). The number of ventilated alveoli and the diameter of the largest ventilated alveolus in each of 10 high-power fields observed on fluorescence micrographs with a tracer of labeled albumin were determined and averaged from 90 to 210 minutes after acid aspiration. RESULTS: The number of alveoli in the PLV group significantly increased in comparison to that in the ALI group. The diameter of the largest alveolus in the PLV group decreased from 103.7 +/- 16.3 microm to 76.3 +/- 6.5 microm until the end of the experiment. This diameter was equivalent to that in the control group. CONCLUSIONS:
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Authors | Shunsuke Endo, Yasunori Sohara, Fumio Murayama, Tsutomu Yamaguchi, Tsuyoshi Hasegawa, Yoshihiko Kanai |
Journal | Surgery
(Surgery)
Vol. 133
Issue 2
Pg. 207-15
(Feb 2003)
ISSN: 0039-6060 [Print] United States |
PMID | 12605182
(Publication Type: Journal Article)
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Chemical References |
- Albumins
- Hydrochloric Acid
- Oxygen
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Topics |
- Acute Disease
- Albumins
(pharmacokinetics)
- Animals
- Blood Pressure
- Computer Systems
- Disease Models, Animal
- Heart Rate
- Hydrochloric Acid
- Liquid Ventilation
- Male
- Microcirculation
- Microscopy, Fluorescence
- Oxygen
(blood)
- Pulmonary Alveoli
(blood supply, physiopathology)
- Rats
- Rats, Wistar
- Respiration, Artificial
(adverse effects)
- Respiratory Distress Syndrome
(chemically induced, physiopathology)
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