[Cutaneous T-cell lymphoma following renal transplantation].

Abstract

INTRODUCTION:

Post-transplant cutaneous lymphomas are the second skin cancer after cutaneous carcinoma and are usually of the B-cell type. Post-transplant cutaneous T-cell lymphomas are extremely rare. We described a case of a cutaneous T-cell lymphoma in a renal transplant recipient.

CASE REPORT:

A 52-year-old woman was hospitalized for an erythematous infiltrated eruption. Seven years earlier, she had undergone kidney transplantation. No palpable lymphadenopathy or hepatosplenomegaly was present. The patient's skin biopsy specimen was histologically suggestive of CD30- fungoid mycosis. The same clonal TCR-rearrangement was identified in the blood and in the skin. No EBV was detected within the cutaneous lesion on immunohistochemical analysis or by PCR in the blood. Chlorambucil (Chloraminophène) was associated with a topical treatment with chlormethine (Caryolysine) and corticosteroids while tacrolimus (Prograf) was reduced and stopped. There was no evidence of recurrence of the lymphoma after 12 months of follow-up.

DISCUSSION:

The particularity of our observation is the apparition, 7 years after transplantation, of a CD30-, EBV-fungoid mycosis with a blood and cutaneous clonal TCR-rearrangement. Despite this poor prognosis factor, the cutaneous lymphoma regressed after reduction of the immunosuppressive treatment reduction and institution of topical corticosteroids, chlormethine and chlorambucil.

• Authors: C Defossez-Tribout, E Carmi, C Lok, P-F Westeel, D Chatelain, J-P Denoeux
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 130 Issue 1 Pt 1 Pg. 47-9 (Jan 2003) ISSN: 0151-9638 [Print] France
• Vernacular Title: Lymphome T cutané après transplantation rénale.
• PMID: 12605158 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Female
• Humans
• Kidney Transplantation (adverse effects)
• Lymphoma, T-Cell, Cutaneous (etiology)
• Middle Aged
• Skin Neoplasms (etiology)