Abstract |
To study the relationship between the infection of enteroviruses and the etiology of keshan disease, we examined the 30 blood samples from the latent-chronic KD patients from Mianning, Xider, Derchang county of Sichuan Province with LDE-PCR (long distance enterovirus-specific RT PCR), two sensitive and specific ELISAs (one for CVB1-6 IgM and the other for CVB1-6 IgG), and three-primer RT PCR specific for CVB3. Results show that: 1) The infection rate of enteroviruses in the samples from the latent-chronic KD patients is higher than from the control group (80% VS 0%, P < 0.01); 2) The CVB1-6 antibody positive rate in latent-chronic KD is higher than that of the control group ( IgM, 33% VS 0%, P < 0.01; IgG, 23% VS 0%, P < 0.01); 3) 16.6% (4/24) of enteroviruses positive samples or 40% (4/10) of CVB1-6 IgM antibody positive samples can be identified as CVB3. So, the infection of enter viruses maybe involves in the cause and development of latent-chronic keshan disease, and at least we conclude that the mutation of CVB3 is not the only cause of KD.
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Authors | Zhenwu Huang, Yiming Xia, Qi Jin, Hongying Wu |
Journal | Wei sheng yan jiu = Journal of hygiene research
(Wei Sheng Yan Jiu)
Vol. 31
Issue 4
Pg. 261-3
(Aug 2002)
ISSN: 1000-8020 [Print] China |
PMID | 12600035
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Immunoglobulin G
- Immunoglobulin M
- Selenium
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Topics |
- Adolescent
- Adult
- Antibodies, Viral
(blood)
- Cardiomyopathies
(etiology, immunology, virology)
- Child
- Child, Preschool
- Enterovirus
(immunology, isolation & purification)
- Enterovirus B, Human
(immunology, isolation & purification)
- Enterovirus Infections
- Female
- Humans
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Male
- Selenium
(deficiency)
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