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[Coxsackievirus B3 infection and Keshan disease].

Abstract
To study the relationship between the infection of enteroviruses and the etiology of keshan disease, we examined the 30 blood samples from the latent-chronic KD patients from Mianning, Xider, Derchang county of Sichuan Province with LDE-PCR (long distance enterovirus-specific RT PCR), two sensitive and specific ELISAs (one for CVB1-6 IgM and the other for CVB1-6 IgG), and three-primer RT PCR specific for CVB3. Results show that: 1) The infection rate of enteroviruses in the samples from the latent-chronic KD patients is higher than from the control group (80% VS 0%, P < 0.01); 2) The CVB1-6 antibody positive rate in latent-chronic KD is higher than that of the control group (IgM, 33% VS 0%, P < 0.01; IgG, 23% VS 0%, P < 0.01); 3) 16.6% (4/24) of enteroviruses positive samples or 40% (4/10) of CVB1-6 IgM antibody positive samples can be identified as CVB3. So, the infection of enter viruses maybe involves in the cause and development of latent-chronic keshan disease, and at least we conclude that the mutation of CVB3 is not the only cause of KD.
AuthorsZhenwu Huang, Yiming Xia, Qi Jin, Hongying Wu
JournalWei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 31 Issue 4 Pg. 261-3 (Aug 2002) ISSN: 1000-8020 [Print] China
PMID12600035 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M
  • Selenium
Topics
  • Adolescent
  • Adult
  • Antibodies, Viral (blood)
  • Cardiomyopathies (etiology, immunology, virology)
  • Child
  • Child, Preschool
  • Enterovirus (immunology, isolation & purification)
  • Enterovirus B, Human (immunology, isolation & purification)
  • Enterovirus Infections
  • Female
  • Humans
  • Immunoglobulin G (blood)
  • Immunoglobulin M (blood)
  • Male
  • Selenium (deficiency)

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