Clearance of indocyanine green as an index of liver function during cyclopropane anaesthesia and induced hypotension.

Abstract

The rate of decrease in the plasma concentration of indocyanine green (ICG) following a bolus i.v. injection has been studied in two groups of patients before and during anaesthesia. In eight patients anaesthetized with nitrous oxide and oxygen, and who received a neuromuscular blocking drug, induction of anaesthesia was not associated with a significant change in ICG half-life (from 4.59 to 3.85 min) but the subsequent administration of cyclopropane was associated with a statistically significant increase to 5.61 min. In a second group of anaesthetized patients, breathing spontaneously a mixture of oxygen, nitrous oxide and halothane, the induction of arterial hypotension with either lumbar extradural block or sodium nitroprusside was not associated with significant changes in ICG half-life.

• Authors: A R Abdel Salam, G B Drummond, H W Bauld, D B Scott
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 48 Issue 3 Pg. 231-8 (Mar 1976) ISSN: 0007-0912 [Print] England
• PMID: 1259889 (Publication Type: Journal Article)

Chemical References

• Cyclopropanes
• Nitroprusside
• Indocyanine Green

Topics

• Adult
• Anesthesia, Epidural
• Anesthesia, Inhalation
• Blood Pressure
• Cyclopropanes
• Female
• Heart Rate
• Humans
• Hypotension, Controlled
• Indocyanine Green (metabolism)
• Liver (metabolism)
• Liver Function Tests
• Middle Aged
• Nitroprusside