Abstract | OBJECTIVES: METHODS: RESULTS: Immediately after whole bladder irradiation, histologic examination of biopsies taken from flat suspicious lesions showed no viable cells; remnants of malignant cells were found in papillary tumors. Of the 12 patients, 11 returned for follow-up examination. At a median follow-up of 18 months (range 3 to 25), 3 of the 7 patients with carcinoma in situ and 2 of the 4 patients with papillary tumors were free of disease. In all patients, urinary frequency and urgency subsided within 3 weeks. No decreased bladder capacity or systemic side effects were observed. CONCLUSIONS: Our preliminary data show that whole bladder photodynamic therapy with intravesically applied 5-aminolevulinic acid using a white light source is effective in destroying flat malignant lesions of the bladder such as carcinoma in situ. The procedure is easy to perform and is not associated with any major side effects. The findings warrant long-term and multicenter studies.
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Authors | R Waidelich, W Beyer, R Knüchel, H Stepp, R Baumgartner, J Schröder, A Hofstetter, M Kriegmair |
Journal | Urology
(Urology)
Vol. 61
Issue 2
Pg. 332-7
(Feb 2003)
ISSN: 1527-9995 [Electronic] United States |
PMID | 12597941
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Administration, Intravesical
- Aminolevulinic Acid
(administration & dosage, therapeutic use)
- Biopsy
- Carcinoma in Situ
(drug therapy, pathology)
- Carcinoma, Transitional Cell
(drug therapy, pathology)
- Follow-Up Studies
- Humans
- Photochemotherapy
(adverse effects, methods)
- Photosensitizing Agents
(administration & dosage, therapeutic use)
- Treatment Outcome
- Urinary Bladder Neoplasms
(drug therapy, pathology)
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