Nitroprusside-induced cyanide poisoning: antidotal effect of hydroxocobalamin.

Abstract

Sodium nitroprusside was investigated as a potential source of cyanide poisoning, Whole-blood cyanide determinations were performed on arterial samples from baboons receiving nitroprusside while anesthetized. There was a statistically significant increase in cyanide levels, as well as development of tachyphylaxis and severe metabolic acidosis. Hydroxocobalamin (vitamin B12a) infused simultaneously with nitroprusside significantly lessened the increase in cyanide levels and eliminated the development of metabolic acidosis. Nitroprusside can cause cyanide intoxication in the baboon, and hydroxocobalamin appears to be an effective antidote.

• Authors: M A Posner, F L Rodkey, R E Tobey
• Journal: Anesthesiology (Anesthesiology) Vol. 44 Issue 4 Pg. 330-5 (Apr 1976) ISSN: 0003-3022 [Print] United States
• PMID: 1259191 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Ferricyanides
• Nitroprusside
• Hydroxocobalamin

Topics

• Acid-Base Equilibrium
• Animals
• Ferricyanides (adverse effects)
• Hydroxocobalamin (therapeutic use)
• Nitroprusside (adverse effects)
• Papio