Abstract | OBJECTIVES: METHODS: We succeeded in producing an animal model of acute and transient facial nerve paralysis induced with HSV-1 neuritis simulating human Bell's palsy. In this study, acyclovir administration was performed before and after facial nerve paralysis, and continued for 5 days. Controls were given phosphate- buffer saline (PBS) instead of acyclovir, and the incidence and duration of facial nerve paralysis was compared in the acyclovir groups and controls. RESULTS: The incidence of facial nerve paralysis was significantly lower in the group given acyclovir before the paralysis than in the controls, and the duration of facial nerve paralysis was shorter. CONCLUSIONS:
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Authors | Hirotaka Takahashi, Naohito Hato, Nobimitsu Honda, Hisanobu Kisaki, Hiroyuki Wakisaka, Shuichi Matsumoto, Kiyofimi Gyo |
Journal | Auris, nasus, larynx
(Auris Nasus Larynx)
Vol. 30
Issue 1
Pg. 1-5
(Feb 2003)
ISSN: 0385-8146 [Print] Netherlands |
PMID | 12589842
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Acyclovir
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Topics |
- Acyclovir
(pharmacology)
- Animals
- Antiviral Agents
(pharmacology)
- Bell Palsy
(drug therapy, virology)
- Data Interpretation, Statistical
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Female
- Herpes Simplex
(complications, drug therapy)
- Mice
- Mice, Inbred BALB C
- Time Factors
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