Abstract | BACKGROUND: The radiographic changes of Mycobacterium avium complex (MAC) pulmonary disease during therapy have not been studied well. OBJECTIVE: METHOD: We analyzed chest CT scans before and after antituberculous therapy in 30 patients (21 women, 9 men) with MAC pulmonary disease. To evaluate radiographic changes during therapy, we defined a 'degree of improvement' (DI) that is calculated according to the CT appearance. RESULTS: DI was better (1.35 +/- 0.21) in patients who had converted sputum culture than in those who had not (0.44 +/- 0.25) (p < 0.05). In patients who were diagnosed by bronchial washing, DI was better (1.60 +/- 0.22) than in patients who were diagnosed by sputum (0.67 +/- 0.20) (p < 0.01). We categorized the CT appearance into 6 types: small nodules, cavities, bronchial wall thickening, infiltration, pleural thickening and atelectasis. Patients who showed pleural thickening had a significantly worse DI (0.12 +/- 0.40) than those who did not (1.23 +/- 0.18) (p < 0.01). Most of the lesions that disappeared after therapy were small nodules. CONCLUSION:
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Authors | Satoru Fujiuchi, Hiroyuki Matsumoto, Yasuhiro Yamazaki, Shoko Nakao, Masaaki Takahashi, Kazue Satoh, Akinori Takeda, Kiyotaka Okamoto, Yuka Fujita, Toshiaki Fujikane, Tetsuo Shimizu |
Journal | Respiration; international review of thoracic diseases
(Respiration)
2003 Jan-Feb
Vol. 70
Issue 1
Pg. 76-81
ISSN: 0025-7931 [Print] Switzerland |
PMID | 12584395
(Publication Type: Journal Article)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- Anti-Bacterial Agents
- Antitubercular Agents
- Ethambutol
- Clarithromycin
- Rifampin
- Streptomycin
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Antitubercular Agents
(therapeutic use)
- Clarithromycin
(therapeutic use)
- Ethambutol
(therapeutic use)
- Female
- Humans
- Logistic Models
- Lung Diseases
(diagnostic imaging, drug therapy, microbiology)
- Male
- Middle Aged
- Mycobacterium avium Complex
- Mycobacterium avium-intracellulare Infection
(diagnostic imaging, drug therapy)
- Predictive Value of Tests
- Rifampin
(therapeutic use)
- Streptomycin
(therapeutic use)
- Tomography, X-Ray Computed
- Treatment Outcome
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