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Serotonin transporter gene polymorphism and schizoid personality traits in the patients with psychosis and psychiatrically well subjects.

AbstractBACKGROUND AND OBJECTIVES:
serotonin transporter (5-HTT) gene allelic variants were shown to be associated with Neuroticism and Harm Avoidance but the results were not replicated in other studies. The current investigation was undertaken in a further attempt to study the relationship between 5-HTT polymorphism and personality traits.
SUBJECTS AND METHODS:
to evaluate a spectrum of personality traits, MMPI was administered to a sample including patients with affective disorders (n=114), patients with schizophrenia spectrum illnesses (n=110) and psychiatrically well controls (n=124). All groups were genotyped for VNTR-17 and functional insertion-deletion (5-HTTLPR) polymorphisms.
RESULTS:
an association was found between 5-HTTLPR polymorphism and scores on three MMPI scales: Psychopathic deviance, Paranoia and Schizophrenia in patients with affective disorders and S chizophrenia in normal subjects. Both affected and control individuals with 'ss' genotype exhibited lower scores on these scales.
CONCLUSION:
we demonstrated that functional deletion/insertion allelic variation associated with decreased expression of serotonin transporter ('s' allele or 'ss' genotype) may restrict expression of schizoid traits in normal subjects and patients with affective disorders.
AuthorsVera E Golimbet, Margarita V Alfimova, Tatyana Shcherbatikh, Vasili G Kaleda, Lilia I Abramova, Evgeni I Rogaev
JournalThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (World J Biol Psychiatry) Vol. 4 Issue 1 Pg. 25-9 (Jan 2003) ISSN: 1562-2975 [Print] England
PMID12582974 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
Topics
  • Adult
  • Alleles
  • Carrier Proteins (genetics)
  • Female
  • Gene Expression (genetics)
  • Genotype
  • Humans
  • MMPI
  • Male
  • Membrane Glycoproteins (genetics)
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Polymerase Chain Reaction
  • Polymorphism, Genetic (genetics)
  • Psychotic Disorders (complications)
  • Schizoid Personality Disorder (complications, diagnosis, genetics)
  • Serotonin Plasma Membrane Transport Proteins
  • Severity of Illness Index

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