Abstract | BACKGROUND AND OBJECTIVES:
serotonin transporter (5-HTT) gene allelic variants were shown to be associated with Neuroticism and Harm Avoidance but the results were not replicated in other studies. The current investigation was undertaken in a further attempt to study the relationship between 5-HTT polymorphism and personality traits. SUBJECTS AND METHODS: to evaluate a spectrum of personality traits, MMPI was administered to a sample including patients with affective disorders (n=114), patients with schizophrenia spectrum illnesses (n=110) and psychiatrically well controls (n=124). All groups were genotyped for VNTR-17 and functional insertion-deletion (5-HTTLPR) polymorphisms. RESULTS: an association was found between 5-HTTLPR polymorphism and scores on three MMPI scales: Psychopathic deviance, Paranoia and Schizophrenia in patients with affective disorders and S chizophrenia in normal subjects. Both affected and control individuals with 'ss' genotype exhibited lower scores on these scales. CONCLUSION: we demonstrated that functional deletion/insertion allelic variation associated with decreased expression of serotonin transporter ('s' allele or 'ss' genotype) may restrict expression of schizoid traits in normal subjects and patients with affective disorders.
|
Authors | Vera E Golimbet, Margarita V Alfimova, Tatyana Shcherbatikh, Vasili G Kaleda, Lilia I Abramova, Evgeni I Rogaev |
Journal | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
(World J Biol Psychiatry)
Vol. 4
Issue 1
Pg. 25-9
(Jan 2003)
ISSN: 1562-2975 [Print] England |
PMID | 12582974
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Carrier Proteins
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- SLC6A4 protein, human
- Serotonin Plasma Membrane Transport Proteins
|
Topics |
- Adult
- Alleles
- Carrier Proteins
(genetics)
- Female
- Gene Expression
(genetics)
- Genotype
- Humans
- MMPI
- Male
- Membrane Glycoproteins
(genetics)
- Membrane Transport Proteins
- Nerve Tissue Proteins
- Polymerase Chain Reaction
- Polymorphism, Genetic
(genetics)
- Psychotic Disorders
(complications)
- Schizoid Personality Disorder
(complications, diagnosis, genetics)
- Serotonin Plasma Membrane Transport Proteins
- Severity of Illness Index
|