Non-functioning adrenal cortical carcinoma presenting with metastasis to the tongue.

Abstract

We report a case of non-functioning adrenal cortical carcinoma (ACC) presenting with metastatic disease to the tongue, which is an extremely uncommon onset for this neoplasm. Histologically, the lesion had the appearance of an anaplastic neoplasm, and a panel of immunohistochemical markers including vimentin, MART-1, S100 protein, HMB-45, smooth muscle actin, common muscle actin, desmin, CD31, CD34, CD68, EMA and cytokeratins, was helpful in excluding melanoma, as well as other mesenchymal and epithelial neoplasms.

• Authors: Alberto Dominici, Michelangelo Rizzo, Fabrizio Travaglini, Gabriella Nesi, Alessandro Franchi
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 32 Issue 3 Pg. 185-7 (Mar 2003) ISSN: 0904-2512 [Print] Denmark
• PMID: 12581389 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Neoplasm
• MART-1 Antigen
• MLANA protein, human
• Neoplasm Proteins
• Vimentin

Topics

• Adrenal Gland Neoplasms (pathology)
• Adrenalectomy
• Adrenocortical Carcinoma (pathology, secondary)
• Anaplasia
• Antigens, Neoplasm (analysis)
• Fatal Outcome
• Humans
• MART-1 Antigen
• Middle Aged
• Neoplasm Proteins (analysis)
• Tongue Neoplasms (pathology, secondary)
• Vimentin (analysis)