Abstract | OBJECTIVE: DESIGN: Randomized, controlled clinical trial. PARTICIPANTS: Forty-one patients (41 eyes) with corneal perforations up to 3 mm in diameter with a positive Seidel's test were randomly assigned to two groups (1 and 2). INTERVENTION: MAIN OUTCOME MEASURES: Number of eyes with successful healing, time required for healing, status of corneal vascularization, and complications were compared in the two groups. Power calculation was performed at alpha = 0.05. RESULTS: Fifteen (79%) eyes had successful healing of corneal perforation in group 1, compared with 19 (86%) eyes in group 2 (P > 0.05) at 3 months' follow-up. The power to detect a difference between the two groups was 10%. Corneal perforation healed within 6 weeks in 12 (63%) eyes in group 1 and 7 (31.8%) eyes in group 2 (P < 0.05). Reapplication of glue was required in six (31.5%) eyes in group 1 and seven (31.4%) eyes in group 2 during the first 3 months of follow-up. The mean number of applications per eye was 1.37 in group 1 and 1.36 in group 2. An increase in deep corneal vascularization was observed in 2 (10.5%) eyes in group 1 and 10 (45.5%) eyes in group 2 (P < 0.05). Giant papillary conjunctivitis occurred in one (5%) eye in group 1 and eight (36.4%) eyes in group 2 (P < 0.05). CONCLUSIONS:
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Authors | Ashok Sharma, Ravinder Kaur, Sudarshan Kumar, Pankaj Gupta, Surinder Pandav, Bijayananda Patnaik, Amod Gupta |
Journal | Ophthalmology
(Ophthalmology)
Vol. 110
Issue 2
Pg. 291-8
(Feb 2003)
ISSN: 0161-6420 [Print] United States |
PMID | 12578769
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Fibrin Tissue Adhesive
- Tissue Adhesives
- Enbucrilate
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Corneal Diseases
(therapy)
- Corneal Injuries
- Enbucrilate
(analogs & derivatives, therapeutic use)
- Eye Injuries
(therapy)
- Female
- Fibrin Tissue Adhesive
(therapeutic use)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Safety
- Tissue Adhesives
(therapeutic use)
- Treatment Outcome
- Wound Healing
(physiology)
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